| Date | Location | Result | |
| Nov 25, 2022 | Bradford, Pa. | Port Allegany 42, Reynolds 8 | Box score |
| Nov 26, 2022 | Pittsburgh, Pa. | Westinghouse 34, Farrell 6 | Box score |
| Nov 25, 2022 | Grove City, Pa. | Martinsburg Central 35, Grove City 7 | Box score |
| Nov. 20 2022 | Titusville, Pa. | Reynolds 28, Eisenhower 14 | Box score |
| Nov. 19 2022 | New Wilmington, Pa. | Farrell 26, Sharpsville 0 | Box score |
| Nov 18, 2022 | Slippery Rock, Pa. | Grove City 42, Slippery Rock 23 | Box score |
| Nov 11, 2022 | Farrell, Pa. | Grove City 22, Sharon 21 | Box score |
| Nov 12, 2022 | New Wilmington, Pa. | Farrell 48, Seneca 6 | Box score |
| Nov 12 2022 | Farrell, Pa. | Reynolds 44, Maplewood 6 | Box score |
| Nov 12, 2022 | Farrell, Pa. | Sharpsville 21, Mercyhurst Prep 14 | Box score |
| Nov 11, 2022 | Wilmington, Pa. | Slippery Rock 28, Hickory 0 | Box score |
| Nov 5 2022 | Erie, Pa. | Mercyhurst Prep 21, Wilmington 14 | Box score |
| Nov 4 2022 | Greenville, Pa. | Sharon 28, Fort LeBoeuf 21 | Box score |
| Nov 4, 2022 | Edinboro, Pa. | Hickory 33, General McLane 28 | Box score |
| Nov 5, 2022 | Meadville, Pa. | Cambridge Springs 21, Mercer 14 | Box score |
| Nov 4, 2022 | Titusville, Pa. | Slippery Rock 41, Oil City 28 | Box score |
| Nov 05, 2022 | Farrell, Pa. | Maplewood 33, Lakeview 24 | Box score |
| Nov 04, 2022 | Farrell, Pa. | Grove City 35, Fairview 21 | Box score |
| Oct 28 2022 | North East, Pa. | Reynolds 26, North East 20 | Box score |
| Oct 28 2022 | Harborcreek, Pa. | Greenville 21, Harbor Creek 7 | Box score |
| Oct 28 2022 | Sharpsville, Pa. | Sharpsville 35, Fort LeBoeuf 28 | Box score |
| Oct 28, 2022 | Stoneboro, Pa. | Lakeview 35, Franklin 8 | Box score |
| Oct 28, 2022 | Erie, Pa. | Mercyhurst Prep 49, Mercer 0 | Box score |
| Oct 21, 2022 | Transfer, Pa. | Reynolds 42, Lakeview 14 | Box score |
| Oct 21 2022 | Cambridge Springs Pa | Cambridge Springs 32, Mercer 22 | Box score |
| Oct 21 2022 | Hermitage, Pa. | Sharpsville 28, Hickory 21 | Box score |
| Oct 21 2022 | Greenville, Pa. | Sharon 47, Greenville 6 | Box score |
| Oct 22 2022 | Hermitage, Pa. | Kennedy Catholic 41, Saegertown 27 | Box score |
| Oct 21 2022 | New Wilmington, Pa. | Grove City 35, Wilmington 6 | Box score |
| Oct 21 2022 | Farrell, Pa. | Farrell 41, Slippery Rock 0 | Box score |
| Oct 14 2022 | Sharon, Pa. | Farrell 42, Sharon 14 | Box score |
| Oct 14 2022 | Hermitage, Pa. | Hickory 45, Greenville 12 | Box score |
| Oct 14 2022 | Saegertown, Pa. | Reynolds 78, Saegertown 12 | Box score |
| Oct 14, 2022 | Guys Mills, Pa. | Maplewood 31, Kennedy Catholic 22 | Box score |
| Oct 14, 2022 | Slippery Rock, Pa. | Slippery Rock 41, Wilmington 13 | Box score |
| Oct 14, 2022 | Sharpsville, Pa. | Grove City 38, Sharpsville 22 | Box score |
| Oct 14, 2022 | Mercer, Pa. | Mercer 15, Lakeview 13 | Box score |
| Oct 7, 2022 | Transfer, Pa. | Reynolds 2, Cochranton 0 | Box score |
| Oct 7, 2022 | Cambridge Springs Pa | Lakeview 41, Cambridge Springs 14 | Box score |
| Oct 7 2022 | Greenville, Pa. | Greenville 50, Iroquois 0 | Box score |
| Oct 7, 2022 | Slippery Rock, Pa. | Sharon 20, Slippery Rock 6 | Box score |
| Oct 7 2022 | New Wilmington, Pa. | General McLane 22, Wilmington 19 | Box score |
| Oct 7 2022 | West Middlesex, Pa. | Farrell 48, Sharpsville 7 | Box score |
| Oct 08, 2022 | Mercer, Pa. | Mercer 43, Kennedy Catholic 7 | Box score |
| Oct 07, 2022 | Grove City, Pa. | Hickory 24, Grove City 14 | Box score |
| Sept 30 2022 | Cochranton, Pa. | Lakeview 35, Cochranton 14 | Box score |
| Sept 30 2022 | Sharon, Pa. | Sharpsville 49, Sharon 27 | Box score |
| Sept 30 2022 | Guys Mills, Pa. | Mercer 28, Maplewood 7 | Box score |
| Oct 1, 2022 | Hermitage, Pa. | Reynolds 50, Kennedy Catholic 6 | Box score |
| Sept 30 2022 | Farrell, Pa. | Farrell 42, Wilmington 13 | Box score |
| Oct 1, 2022 | Greenville, Pa. | Grove City 33, Greenville 27 | Box score |
| Sep 30, 2022 | Hermitage, Pa. | Slippery Rock 23, Hickory 20 | Box score |
| Sept 23 2022 | Mercer, Pa. | Mercer 45, Cochranton 0 | Box score |
| Sept 23 2022 | Transfer, Pa. | Reynolds 64, Maplewood 0 | Box score |
| Sept 24 2022 | Hermitage, Pa. | St. John's Prep (Md) 27, Kennedy Catholic 13 | Box score |
| Sept 23 2022 | Stoneboro, Pa. | Eisenhower 35, Lakeview 13 | Box score |
| Sept 24 2022 | Farrell, Pa. | Farrell 35, Hickory 0 | Box score |
| Sept 23 2022 | New Wilmington, Pa. | Sharon 33, Wilmington 14 | Box score |
| Sept 23 2022 | Sharpsville, Pa. | Sharpsville 14, Greenville 12 | Box score |
| Sep 23, 2022 | Grove City, Pa. | Grove City 22, Slippery Rock 21 | Box score |
| Sep 16, 2022 | Saegertown, Pa. | Mercer 42, Saegertown 24 | Box score |
| Sep 16, 2022 | Greenville, Pa. | Farrell 46, Greenville 7 | Box score |
| Sep 16, 2022 | Guys Mills, Pa. | Lakeview 24, Maplewood 7 | Box score |
| Sep 17, 2022 | Cochranton, Pa. | Kennedy Catholic 22, Cochranton 0 | Box score |
| Sep 16, 2022 | Cambridge Springs Pa | Reynolds 46, Cambridge Springs 6 | Box score |
| Sep 16, 2022 | Slippery Rock, Pa. | Sharpsville 28, Slippery Rock 14 | Box score |
| Sep 16, 2022 | Hermitage, Pa. | Wilmington 22, Hickory 21 | Box score |
| Sep 16, 2022 | Sharon, Pa. | Grove City 41, Sharon 25 | Box score |
| Sep 9, 2022 | Stoneboro, Pa. | Lakeview 51, Kennedy Catholic 14 | Box score |
| Sep 9, 2022 | Transfer, Pa. | Sharpsville 41, Reynolds 27 | Box score |
| Sept 9 2022 | Mercer, Pa. | Wilmington 50, Mercer 8 | Box score |
| Sept 9 2022 | Slippery Rock, Pa. | Slippery Rock 24, Greenville 7 | Box score |
| Sep 09, 2022 | Sharon, Pa. | Sharon 28, Hickory 14 | Box score |
| Sep 09, 2022 | Grove City, Pa. | Farrell 46, Grove City 15 | Box score |
| Sep 03, 2022 | Farrell, Pa. | Ursuline 40, Farrell 38 | Box score |
| Sep 02, 2022 | Sharon, Pa. | Sharon 42, Warren 0 | Box score |
| Sept 2 2022 | Hermitage, Pa. | Hickory 62, Franklin 3 | Box score |
| Sep 02, 2022 | Titusville, Pa. | Sharpsville 40, Titusville 14 | Box score |
| Sep 02, 2022 | Slippery Rock, Pa. | Slippery Rock 38, Mercyhurst Prep 24 | Box score |
| Sep 02, 2022 | Union City, Pa. | Union City 26, Kennedy Catholic 20 | Box score |
| Sep 02, 2022 | Grove City, Pa. | Grove City 42, Northwestern 7 | Box score |
| Sep 02, 2022 | New Wilmington, Pa. | Wilmington 14, Greenville 7 | Box score |
| Sep 02, 2022 | Mercer, Pa. | Reynolds 47, Mercer 0 | Box score |
| Sept 1 2022 | Stoneboro, Pa. | Lakeview 35, Saegertown 15 | Box score |
| Aug 27, 2022 | Sharpsville, Pa. | Sharpsville 23, Wilmington 0 | Box score |
| Aug 27, 2022 | Hermitage, Pa. | Cambridge Springs 35, Kennedy Catholic 18 | Box score |
| Aug 26 2022 | New Castle, Pa. | Neshannock 45, Sharon 28 | Box score |
| Aug 26 2022 | New Wilmington, Pa. | Farrell 50, North East 20 | Box score |
| Aug 26 2022 | Erie, Pa. | Mercer 38, Iroquois 7 | Box score |
| Aug 26 2022 | Harborcreek Twp, Pa. | Hickory 14, Harbor Creek 10 | Box score |
| Aug 26 2022 | Wattsburg, Pa. | Seneca 40, Lakeview 13 | Box score |
| Aug 26, 2022 | Transfer, Pa. | Reynolds 58, Union City 6 | Box score |
| Aug 26, 2022 | Edinboro, Pa. | Slippery Rock 37, General McLane 20 | Box score |
| Aug 26 2022 | Greenville, Pa. | Hubbard 8, Greenville 3 | Box score |
| Aug 26, 2022 | Emsworth, Pa. | Avonworth 27, Grove City 7 | Box score |