| Date | Location | Result | |
| Dec 03, 2021 | Slippery Rock, Pa. | Serra 27, Farrell 18 | Box score |
| Nov 26, 2021 | Karns City, Pa. | Farrell 30, Karns City 12 | Box score |
| Nov 26, 2021 | Slippery Rock, Pa. | Central (Mart'burg) 35, Grove City 6 | Box score |
| Nov 20, 2021 | Slippery Rock, Pa. | Grove City 28, Slippery Rock 20 | Box score |
| Nov 20, 2021 | Pittsburgh, Pa. | Farrell 24, Westinghouse 7 | Box score |
| Nov 19, 2021 | Greenville, Pa. | Northern Bedford Co. 35, Reynolds 22 | Box score |
| Nov 12, 2021 | Grove City, Pa. | Slippery Rock 23, Hickory 17 | Box score |
| Nov 12, 2021 | Hermitage, Pa. | Farrell 48, Wilmington 6 | Box score |
| Nov 13, 2021 | Edinboro, Pa. | Grove City 35, Fort LeBoeuf 21 | Box score |
| Nov 12, 2021 | Greenville, Pa. | Reynolds 23, Cochranton 0 | Box score |
| Nov 05, 2021 | Erie, Pa. | Lakeview 28, Mercyhurst Prep 21 | Box score |
| Nov 05, 2021 | Titusville, Pa. | Reynolds 56, Eisenhower 27 | Box score |
| Nov 06, 2021 | New Wilmington, Pa. | Hickory 36, Sharon 20 | Box score |
| Nov 05, 2021 | Hermitage, Pa. | Farrell 60, Greenville 14 | Box score |
| Nov 06, 2021 | Greenville, Pa. | Grove City 42, Fairview 7 | Box score |
| Nov 05, 2021 | Edinboro, Pa. | Wilmington 41, Northwestern 21 | Box score |
| Oct 29 2021 | Waterford, Pa. | Farrell 48, Fort LeBoeuf 21 | Box score |
| Oct 29 2021 | New Wilmington, Pa. | Reynolds 34, Cambridge Springs 20 | Box score |
| Oct 30, 2021 | Erie, Pa. | Sharpsville 63, Mercyhurst Prep 13 | Box score |
| Oct 29, 2021 | Greenville, Pa. | Greenville 43, Conneaut, Pa. 6 | Box score |
| Oct 30, 2021 | Hermitage, Pa. | Titusville 14, Kennedy Catholic 8 | Box score |
| Oct 30, 2021 | Franklin, Pa. | Lakeview 41, Franklin 40 | Box score |
| Oct 29, 2021 | Oil City, Pa. | Maplewood 19, Mercer 7 | Box score |
| Oct 21, 2021 | Edinboro, Pa. | General McLane 40, Lakeview 8 | Box score |
| Oct 22, 2021 | Girard, Pa. | Slippery Rock 56, Girard 13 | Box score |
| Oct 22, 2021 | Erie, Pa. | Greenville 13, Harbor Creek 6 | Box score |
| Oct 22, 2021 | Farrell, Pa. | Farrell 78, Kennedy Catholic 8 | Box score |
| Oct 22, 2021 | North East, Pa. | Sharon 35, North East 0 | Box score |
| Oct 22, 2021 | Mercer, Pa. | Wilmington 41, Mercer 26 | Box score |
| Oct 22, 2021 | Erie, Pa. | Grove City 42, Mercyhurst Prep 8 | Box score |
| Oct 22, 2021 | Corry, Pa. | Hickory 45, Corry 7 | Box score |
| Oct 22, 2021 | Transfer, Pa. | Sharpsville 21, Reynolds 7 | Box score |
| Oct 15, 2021 | Stoneboro, Pa. | Reynolds 47, Lakeview 27 | Box score |
| Oct 15, 2021 | McDonald, Ohio | Greenville 49, McDonald, Ohio 35 | Box score |
| Oct 16, 2021 | New Wilmington, Pa. | Wilmington 55, Kennedy Catholic 14 | Box score |
| Oct 15, 2021 | Grove City, Pa. | Grove City 20, Hickory 7 | Box score |
| Oct 16, 2021 | Mercer, Pa. | Sharpsville 46, Mercer 0 | Box score |
| Oct 15, 2021 | Slippery Rock, Pa. | Slippery Rock 35, Sharon 33 | Box score |
| Oct 8, 2021 | Transfer, Pa. | Greenville 35, Reynolds 21 | Box score |
| Oct 8, 2021 | Mercer, Pa. | Mercer 20, Lakeview 6 | Box score |
| Oct 9, 2021 | Hermitage, Pa. | Sharpsville 34, Kennedy Catholic 6 | Box score |
| Oct 8, 2021 | New Wilmington, Pa. | Farrell 54, Wilmington 0 | Box score |
| Oct 8, 2021 | Sharon, Pa. | Sharon 48, Conneaut, Ohio 21 | Box score |
| Oct 8, 2021 | Titusville, Pa. | Grove City 42, Titusville 6 | Box score |
| Oct 08, 2021 | Slippery Rock, Pa. | Hickory 27, Slippery Rock 23 | Box score |
| Oct 1, 2021 | Greenville, Pa. | Greenville 28, Mercer 7 | Box score |
| Oct 01, 2021 | Transfer, Pa. | Reynolds 54, Saegertown 28 | Box score |
| Oct 1 2021 | Stoneboro, Pa. | Kennedy Catholic 18, Lakeview 15 | Box score |
| Oct 1 2021 | Conneaut, Ohio | Slippery Rock 49, Conneaut, Ohio 14 | Box score |
| Oct 1 2021 | Hermitage, Pa. | Hickory 56, Titusville 7 | Box score |
| Oct 01, 2021 | Sharpsville, Pa. | Wilmington 28, Sharpsville 27 | Box score |
| Oct 01, 2021 | Sharon, Pa. | Grove City 32, Sharon 13 | Box score |
| Sept 24 2021 | Mercer, Pa. | Mercer 21, Maplewood 7 | Box score |
| Sept 24 2021 | Conneaut, Ohio | Conneaut, Ohio 42, Reynolds 22 | Box score |
| Sept 25 2021 | Hermitage, Pa. | Greenville 50, Kennedy Catholic 14 | Box score |
| Sept 24 2021 | Hermitage, Pa. | Hickory 55, Mercyhurst Prep 13 | Box score |
| Sept 25 2021 | New Wilmington, Pa. | Wilmington 54, Lakeview 22 | Box score |
| Sept 24 2021 | Sharon, Pa. | Sharon 40, Fort LeBoeuf 27 | Box score |
| Sept 24 2021 | Grove City, Pa. | Grove City 41, Fairview 8 | Box score |
| Sep 24, 2021 | Sharpsville, Pa. | Farrell 40, Sharpsville 0 | Box score |
| Sept 17 2021 | Oil City, Pa. | Sharon 23, Oil City 0 | Box score |
| Sept 17 2021 | Jefferson, Ohio | Sharpsville 28, Jefferson, Ohio 21 | Box score |
| Sept 16 2021 | Harborcreek Twp. Pa. | Iroquois 14, Kennedy Catholic 12 | Box score |
| Sept 18 2021 | Greenville, Pa. | Wilmington 42, Greenville 15 | Box score |
| Sept 17 2021 | Hermitage, Pa. | Hickory 41, Conneaut, Ohio 14 | Box score |
| Sep 17, 2021 | Slippery Rock, Pa. | Slippery Rock 34, Grove City 7 | Box score |
| Sept 10 2021 | Mercer, Pa. | Reynolds 26, Mercer 7 | Box score |
| Sept 10 2021 | Stoneboro, Pa. | Farrell 58, Lakeview 6 | Box score |
| Sept 10 2021 | West Middlesex, Pa. | Sharpsville 33, Greenville 7 | Box score |
| Sept 11 2021 | Findlay, Ohio | Liberty-Benton, O. 35, Wilmington 14 | Box score |
| Sept 11 2021 | Sharon, Pa. | Sharon 14, Hickory 7 | Box score |
| Sep 10, 2021 | Grove City, Pa. | Grove City 42, Conneaut, Ohio 20 | Box score |
| Sept 3, 2021 | Farrell, Pa. | Farrell 66, Mercer 0 | Box score |
| Sep 03, 2021 | Greenville, Pa. | Greenville 49, Lakeview 15 | Box score |
| Sep 03, 2021 | Transfer, Pa. | Reynolds 47, Kennedy Catholic 14 | Box score |
| Sept 4, 2021 | Waterford, Pa. | Fort LeBoeuf 17, Grove City 14 | Box score |
| Sep 03, 2021 | Girard, Pa. | Hickory 35, Girard 7 | Box score |
| Sep 04, 2021 | Sharpsville, Pa. | Slippery Rock 35, Sharpsville 10 | Box score |
| Sep 03, 2021 | Sharon, Pa. | University Prep 21, Sharon 14 | Box score |
| Aug 27, 2021 | Titusville, Pa. | Lakeview 41, Titusville 7 | Box score |
| Aug 27, 2021 | Greenville, Pa. | Farrell 58, Greenville 0 | Box score |
| Aug 27, 2021 | Sharpsville, Pa. | Sharpsville 7, Loudonville 6 | Box score |
| Aug 27, 2021 | Slippery Rock, Pa. | Slippery Rock 38, Central Clarion 7 | Box score |
| Aug 28, 2021 | Corry, Pa. | Sharon 49, Corry 0 | Box score |
| Aug 27, 2021 | New Wilmington, Pa. | Wilmington 50, Reynolds 0 | Box score |
| Aug 27 2021 | Hermitage, Pa. | Ursuline 50, Hickory 7 | Box score |
| Aug 28, 2021 | Hermitage, Pa. | Mercer 45, Kennedy Catholic 16 | Box score |
| Aug 27, 2021 | Grove City, Pa. | Grove City 50, Meadville 48 | Box score |